Our lab works at the interface between physics, nanotechnology, and biology.

  • we build cutting-edge biophysical tools to boost advances in biology and to gain fresh sights of nature;
  • and we observe biology and nature to inspire new physics and to apply physics in novel ways.

We combine quantitative super-resolved fluorescence microscopy (the technique winning the 2014 Nobel Prize in Chemistry »), single-molecule nanometric techniques and statistical physics/modeling to study biological systems at various scales, ranging from individual biological macromolecules (proteins, DNA, RNA) to individual cells/bacteria. We aim to understand quantitatively the fundamental physics that controls the central processes that remain unknown/unclear. (read more about the Science in our lab)


  • 01/2018: Congratulations to Jack Freeland for being awarded an Honors College Research Grant!
  • 12/2017: Mohammad’s paper (“An Experiment-Based Model Quantifying Antimicrobial Activity of Silver Nanoparticles on Escherichia coli”, a collaboration with Dr. Chen’s group at University of Arkansas) is formally accepted and published by RSC Advances (see Publication).
  • 10/2017: We receive a grant from the Honors College, which will help us to build the second super-resolution fluorescence microscope in our lab.
  • 09/2017: Congratulations to Sai Divya Challapalli on passing her final defense for her M.S. degree!
  • 09/2017: Jack Jiang’s work is reported by UARK Newswire (link)
  • 07/2017: Congratulations to Mohammad Haque on passing his final defense for his M.S. degree!
  • 06/2017: Our proposal on Ag+ gets funded by Arkansas Biosciences Institute.
  • 06/2017: Jack Jiang’s paper (“Robust nonparametric quantification of clustering density of molecules in single-molecule localization microscopy”, co-authored by Sai Divya and our collaborators) is formally accepted by PLOS ONE.
  • 04/2017: Congratulations to Austin Brown, Collin Brown and Tiffany Marcelle in our lab for winning several physics scholarships.
  • 03/2017: Our paper “Spatial distribution of high copy number plasmids in bacteria” is now published in Plasmids.
  • 06/2016: Our paper “Quantitative localization microscopy in combination with DNA smFISH reveals new features of the organization of high-copy number plasmids in bacteria” is formally accepted by Biophysical Journal.
  • 06/2016: Our proposal on plasmids gets funded by Arkansas Biosciences Institute.
  • 04/2016: Sai Divya Challapalli gave a poster presentation at the 100th Arkansas Academy of Science Meeting.


The research in our lab has been supported by the following funding agencies.

University of Arkansas    HFSP    ABI    University of Arkansas Honors College